People may call it Lewis Drug, Lewis Family Drug, or just Lewis. But, they all are talking about an icon of Sioux Falls's history and the center of many neighborhoods in the city. Now, another neighborhood in Sioux Falls will be home to a Lewis.

Lewis Drug Stores is excited to announce its newest location at 5830 E. Madison Street and Veterans Parkway in Sioux Falls, South Dakota. The store will celebrate its grand opening on March 16 and 17.

At the grand opening celebration, you'll find exclusive discounts and a chance to win a 2024 Mitsubishi Outlander Hybrid!

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Join The Celebration At Lewis Drug's Grand Opening Event In Sioux Falls

New Lewis SIoux falls
5830 E. Madison St, Sioux Falls, SD (Google Maps)

This expansion marks a significant milestone for the company as it continues to grow and serve the community.

The new store will offer all the things you expect to find in Sioux Falls's favorite store. There'll be Lewis's excellent full-service pharmacy as well as grills, patio furniture, garden supplies, wine and spirits, pets, grocery, home essentials, health and wellness products, health and beauty items, toys, giftware, and more.


"We are thrilled to open our doors and welcome the community to our newest location," said Bob Meyer, Sr. Vice President of Merchandising and Marketing at Lewis.

"At Lewis, we are committed to providing an exceptional shopping experience, and we look forward to serving the needs of our guests here at this new location and beyond."

When is the Grand Opening of the New Lewis Store in Sioux Falls?

On March 16 and 17, 2024 Lewis Drug Stores invites the community to explore the new store at Madison Street and Veterans Parkway for their Grand Opening celebration.

Lewis Drug Store E. Madison Street and Veterans Parkway in Sioux Falls

<p>On March 16 and 17, 2024 Lewis Drug Stores invites you to explore the new store at Madison Street and Veterans Parkway for their Grand Opening celebration and a chance to win.</p>

Experience Lewis Drug's Tradition Of Community Service At The New Store

At the grand opening event, you can enjoy an exclusive 20% discount on purchases during the event, participate in giveaways, and meet the Lewis team.

Plus, you'll be able to sign up on the Lewis app to win a 2024 Mitsubishi Outlander Hybrid!

With 61 South Dakota, Iowa, and Minnesota stores, Lewis has been a trusted family-owned neighborhood store and pharmacy since 1942.

For more information visit or Lewis Drug Stores on Facebook.

Who Is the 'Lewis' of Lewis Drug? Here's The Story

To answer the essential question of 'Who is the 'Lewis' of Lewis Drug?', let's take a little trip. Well, actually, more than a little trip. We're hopping into the time machine here.


Ah, here we are. Sioux Falls, South Dakota, 1942.

In many ways, it is not the best of times. What has become known as the Great Depression was still having its effects. It might have been in the rearview mirror, but it lingered still.

And, just a few months before, Pearl Harbor happened and we were into World War II. The country was more than jittery. This was going to be more than tough, this was going to be life-changing.

Gallery Credit: Randy McDaniel

10 Small-Town South Dakota Restaurants That Are Worth The Drive

The Sioux Empire is full of restaurants that are long-known to be local favorites.

Sure, they might be a short drive from home, but you won't regret the experience at these hometown mainstays.

Here are 10 of the best small-town restaurants in South Dakota.

Gallery Credit: Andy Gott

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